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Director: |
Kevin D. Cooper,
MD
Phone: 216-844-3111
Email: kevin.cooper @UHhospitals.org |
Associate Directors: |
Mahmoud A. Ghannoum,
PhD, EMBA
Thomas S. McCormick, PhD
|
Enrichment Director: |
Anita C. Gilliam, MD, PhD |
The Administrative Core
is comprised of the SDRC Director , the Associate
Directors, the Enrichment Director,
the Administrator, the Staff Assistant, the Department Adminisrator,
the Executive
Committee and
the
Pilot and Feasibility
reviewers.
The aims of the Core are to:
- integrate the components of and activities of the SDRC
- manage fiscal operations
- coordinate core facility and pilot and feasibility awarded programs
- implement an Enrichment Program
- foster new SDRC initiative
The Administrative Core solicits, reviews, awards, and guides and monitors the progress of the Pilot and Feasibility Studies. It also ensures accountability of the Research Service Cores, and provides leadership to SDRC members with regard to evolving opportunities and expertise available for skin diseases research.
The Director has demonstrated
a sustained committment to excellence in research and training
and is well qualified to manage all aspects of the SDRC as needed.
Drs. Cooper, Ghannoum, McCormick and Gilliam are active in many
key institutional committees which help them integrate the Case
SDRC into the fabric of the University and to leverage opportunities
for the SDRC.
The Administrative Core
effectively coordinates the Research Cores,
the P&F's
and the Enrichment Programs. The Core also instituted
and manages a highly successful minority
research program, and coordinates
the lectures and seminars that are key for trainees and the research
milieu on
cutaneous biology and skin diseases. The SDRC publishes
a newsletter (Skinergy),
a Core Services Directory and a brochure. An active conference
program is highly collaborative, working with other CWRU Centers,
such as the Comprehensive Cancer Center, the Center for
AIDS Research,
and the GCRC, and was instrumental in coordinating the
skin biology community's component of hte recently awarded multimillion
dollar Clinical Tissure Engineering Center. This Core provides
the integrated functioning of the SDRC as a whole.
For more information
regarding the Administrative Core, contact Minja Greisser
at mag28@case.edu.
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Director: |
Anita C. Gilliam, MD, PhD
Phone: 216-368-0533
Email: acg@case.edu |
Associate
Director: |
David Askew,
PhD
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The Morphology Core (Core
A) has existed since the beginning of the SDRC at our institution.
It has been consistently
a heavily utilized Core providing a diverse array of services to
a large number of SDRC faculty and their associates. In the current
proposal, the principal aim of the CMMC is to continue to provide
state-of-the-art services and expertise to SDRC investigators using
a wide variety of morphological and immunologic studies in which
microscopic analysis plays a central role. The SDRC faculty responsible
for Morphology operations provides access to highly trained technical
personnel in very well equipped research laboratories. An additional
goal is to foster exchange of technical information among SDRC
members and to encourage the sharing of resources.
Key features of this Core are its flexibility in adapting to the
evolving needs of the SDRC faculty, and its comprehensive and innovative
range of services designed to support the needs of both proposed
and future SDRC-related morphological studies.
These services fall into three specific aims:
-
to provide state-of-the-art services, expertise, and cost savings
-
to provide morphologic
techniques and expertise that facilitate a “pipeline” of
translational research
and interdisciplinary projects involving skin research
-
to promote career
development with a skin-centered emphasis
for research residents, fellows,
and faculty members
by helping them to learn
state-of-the-art morphologic
techniques as they build a body of preliminary
data for research
projects.
For more information
regarding the Morphology Core, contact Anita Gilliam, MD, PhD,
at the information provided above
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| Cell
Culture and Molecualr Technology Core (B) |
The SDRC Cell Culture and
Molecular Technology Core (CCMTC) has played an important role in
facilitating skin-based research activity at Case School of Medicine
throughout its fifteen year history. During this time, the Core has
provided basic services and training, state-of-the-art services,
facilities, and expertise. The CCMTC has now developed into a major
hub of research activity on campus and has an active role in introducing
new investigators to work on dermatological disease. The Core is
heavily engaged in providing a wide range of cultured skin cells
to investigators, and in providing training in cell culture methodology
and molecular biology technology.
The three major missions of the CCMTC are:
- to provide state-of-the-art cell culture and molecular technology
services and expertise, in addition to cost savings to the SDRC membership
at Case School of Medicine, and to the larger community of researchers
affiliated with the Case School of Medicine. In addition to the substantial
list of technology that is presently offered, we will now provide access,
expertise and training in advanced real-time fluorescent imaging for
visualization of intracellular protein-protein interaction (FRET, FRAP,
etc.), chip array analysis, and proteomics
- to provide cell and molecular technology, and expertise, that facilitates
and encourages the translation of basic science projects to the
bedside
- to promote career development with a goal of retaining talented,
young PhD and MD investigators in the dermatologic sciences.
This is achieved
by providing training to new investigators and senior investigators
in technologies that will facilitate investigation of dermatologic
diseases and by providing a forum for discussion of dermatologic
science.
For more information
regarding the Cell Culture and Molecular Technology
Core, contact Pratima Karnik, PhD at the information provided above.
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| Translational Research Core (C) |
Director: |
Neil J. Korman, MD, PhD |
Co-Director: |
Elma Baron, MD
Phone: 216-368-4971
Email: edb4@case.edu |
The Translational Research Core is designed
to promote and facilitate human subject research in skin biology and
skin disease.
The aims of the Core are as follows:
- To provide a cost-efficient, central resource to
identify and recruit volunteer to participate in human in vivo
studies and/or donate
blood or skin biopsy tissue for ex vivo/in vivo investigations. The
Core
performs procedures such as skin exposure to simulated solar radiation,
hapten sensitization and elicitation, non-invasive monitoring (e.g.,
ultrasonography, chromometry, transepidermal water loss measurement)
and tissue acquisition (venipuncture, punch & keratome biopsies).
The utilization of these functions are expanded mainly by active
interactions with physicians who refer patients and with other
investigators through
the Case Comprehensive Cancer Center, the General Clinical Research
Center, the Center for AIDS Research, and other research foci within
the University.
- To provide overall management of clinical trials of novel therapies
brought from the laboratory to the bedside with emphasis on providing
optimal translational and clinical data. A group with expertise
in general trial design as well as data and safety monitoring
are assembled
to efficiently direct or conduct high quality studies that arise
through interaction with various investigators interested in
skin research.
Additionally, interactions between clinical and laboratory researchers
are fostered to insert adjunctive laboratory studies to clarify
mechanisms of action therapies and pathomechanisms of disease.
- To foster career development of young investigators and junior
faculty in the area of human subject-based skin research. This
involves providing
support at multiple levels (e.g. IRB submission, protocol design,
data analysis, manuscript preparation) depending on investigator
needs.
For more information
regarding the Translational Research Core, contact Elma Baron,
MD, at the information provided above.
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| Animal
Experimentation Core (D) |
Director: |
Tom McCormick,
PhD
Phone: 216-368-0238
Email: tsm4@case.edu
|
The Skin Diseases Research Center Animal Experimentation
Core is directed by Thomas S. McCormick, PhD. The Animal Core facilitates
investigator use of development of animal models of skin disease.
Creation of new models of diseased skin, characterization of transgenic
and knock-out mice, and skin cancer models using UV simulated solar
radiation, and chemical mortagenesis/initiation, and promotion are
all popular programs among the Core users. Quality procurement, handling,
and interpretation of spontaneous phenotypes or those that are elicited
via barrier description, contact dermatitis, UV, or microorganisms,
or or production of skin and skin tumors facilitates histology, homegenates,
and/or cell suspensions, RNA, and DNA that can be used in flow cytometry,
microarray, or proteomic experiments. Experience with athymic nude
and SCID mice enhances experimentation in tissue implantation models,
either using murine tumor cells or xenogenic transplants of human
diseased skin. Also new is a panel of wounding/healing techniques,
and assistance in applying small animal imaging/animal handling to
skin models.
For more information
regarding the Animal Experimentation Core D, contact Tom McCormick,
PhD at the information
provided above.
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