Clinical studies are ongoing to evaluate the efficacy of new therapeutic agents for variety of indications. The staff are experienced in topical, systemic and novel biologic therapeutics. They coordinate trials across multiple locations, including the NIH-funded General Clinical Research Center and the Ireland Cancer Center Infusion Unit. The Clinical Trials Unit (CTU) maintains a professional infrastructure for testing new agents and protocols for patients with skin diseases. The dermatology CTU provides a resource for industry and government for skilled assessment of skin disease. The Department has cultivated a very large pool of patients, both from within the institution and from a large referral base, who are regularly recruited into clinical trials, effecting rapid enrollment. The CTU is actively involved in study design, all phases of clinical testing, and the FDA approval process of investigational new drugs.
The Clinical Trials Unit of the Department of Dermatology provides patients with the opportunity to participate in studies of the newest medications that are being evaluated as potential therapies. Past projects include trials in psoriasis, eczema, skin lymphoma, melanoma, shingles, pemphigus, bullous pemphigoid, alopecia, acne, warts, fungal infections,
onychomycosis, tinea pedis/cruris/versicolor, herpes zoster, genital warts, postherpic neuralgia, Kaposi's sarcoma,
graft vs. host disease, urticaria, and photoaging. All patients seen in our practice are eligible to enroll in such studies which are funded by pharmaceutical, private, or governmental sources.
- Adult open label study to evaluate the effectiveness and
safety of Enbrel in the treatment of adults (ages 18 and
older) with moderate to severe plaqe psoriasis
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- Adults (ages 18 and older) placebo controlled trial with
a topical agent for patients with mild to severe psoriasis
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- The treatment of moderate to severe atopic dermatitis with
Raptiva
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- The treatment of psoriasis with IL-12 antibody
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- The treatment of severe lichen planus with Enbrel
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- The treatment of moderate to severe cutaneous lupus erythematosus
with a new monoclonal antibody
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- Treatment
of cutaneous T cell lymphoma with fully human CD4
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- Effects of green tea cream on cutaneous vasodilatation
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- Treatment of CD30+ lymphoproliferative disorders (lympomatoid
papulosis and CD30+ larc cell lymphoma)
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- Phase 1 clinical trial using topical silicon phthalocyanine
(Pc4) photodynamic therapy (PDT) for the treatment of pre-malignant
and malignant skin conditions (CTCL, AK, BCC, SCC)
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- 06 Benzylguanine-potentiated topical BCNU for CTCL
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- Photpheresis for treatment of early stage cutaneous T cell
lymphoma
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- Mechanisms of excimer laser UV therapy in psoriasis
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For more information regarding our clinical trials,
please call 216-844-7394.
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